TY - JOUR AU - Xiao, Rongxin AU - Li, Yun AU - Zhao, Hui AU - Li, Xiao AU - Wang, Xun AU - Wang, Jun PY - 2019 TI - The value of mediastinoscopy in N staging of clinical N2 lung cancer JF - Mediastinum; Vol 3 (June 2019): Mediastinum Y2 - 2019 KW - N2 - Background: To determine the value of mediastinoscopy in N staging of lung cancer with clinical N2 disease. Methods: We retrospectively reviewed 87 patients who received mediastinoscopy for known or suspected lung cancer, including 83 cervical mediastinoscopies and 4 parasternal mediastinoscopies. All patients were clinically staged N2 for enlarged ipsilateral mediastinal and/or subcarinal lymph nodes (short axis >1.0 cm) on computed tomography scan. Results: Of the 87 patients, 61 cases proved to be N2 disease by mediastinoscopy; the other 26 mediastinoscopy-negative patients underwent thoracotomy for lung resection and mediastinal lymph node dissection in the same operation. Final pathologic N staging was consistent with mediastinoscopic sampling and surgical dissection in 24 patients, and N2 disease was found in 2 patients (false-negative by mediastinoscopy). The sensitivity, specificity, and accuracy of mediastinoscopy were 96.8%, 100%, and 97.7%, respectively. Among all 87 mediastinoscopic procedures, there was no mortality and only 1 complication (1.1%). Conclusions: Mediastinoscopy is a highly effective and safe procedure for the mediastinal staging of lung cancer with clinical N2 disease. UR - https://med.amegroups.org/article/view/5026